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. 2019 Jul 11;14:5147–5157. doi: 10.2147/IJN.S209773

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© 2019 Govindaraju et al.

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MTT assay to evaluate the cytotoxicity of K-AuNCs on HK-2 human normal kidney cells and A549 lung cancer cell line. Two different concentrations of the formulations namely, 12.5 µg/mL and 25 µg/mL were treated to the normal and lung cancer cells. Cells were then incubated for up to 24 hrs. MTT reagent was added to each well and further incubated in dark for 4 hrs. Following this, the OD was recorded. The percentage of viable cells in each group was calculated and plotted as graph. (A) HK-2 human kidney cell line showed very less cytotoxicity (B) A549 human lung cancer cell line on the other hand showed significant increase in cytotoxicity with increasing concentrations of K-AuNCs. Each value represents the mean ± SE (n=5) *p<0.05. Scale bar=200 µm.Note: ***p<0.001.