Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug;26(8):284–290. doi: 10.1101/lm.049577.119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Takemoto and Song; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 5. — Discriminative fear but not safety learning in a paradigm with tone/tone pair of the CSs. (A) Percentage of time spent freezing in trials with the 12 kHz CS− in the testing session with the conditioning context (day 4). No significant difference in the freezing level on average is found between the CS− and the PreCS−, indicating no apparent effect of the CS− on contextual fear in this paradigm. (B) Percentage of time spent freezing in trials with the 4 kHz CS+ on day 4. A significantly higher level of freezing is found for the CS+ compared to the PreCS+. (C) Comparison of the changes in freezing levels from the PreCS period to the CS period on day 4. A significant difference of the changes in freezing levels during the CSs indicates discriminatory responses to the tone CSs. (D) A positive change in the freezing level is found for the 4 kHz CS+ but not for the 12 kHz CS− in the testing session with a novel context (day 5), indicating cued fear selective to the 4 kHz CS+. Gray dots with lines (A–C) and circles (D) represent the median of data sets from three trials for individual mice (n = 12 mice). All data in bar graphs are depicted as mean ± SEM. (***) P < 0.001. P values were obtained using a two-tailed paired t-test (A–C) and a one-tailed paired t-test (D).