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. 2019 Jul 10;13:293. doi: 10.3389/fncel.2019.00293

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Copyright © 2019 Zong, Zhou, Ji, Jia, Tang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early clenbuterol treatment attenuated sepsis-induced hippocampus-dependent cognitive impairments. (A) Schematic timeline of the experimental procedures. The survival rate (B) was significantly decreased in the CLP group than sham group, while early clenbuterol treatment did not improve the survival rate of the sepsis. There was no significant difference at weight (C), ambulatory distance (D) and time spent in the center (F) in the open field test among the four groups at 16 days following CLP. (E) The freezing time to context was significantly decreased in the CLP group than control group, while clenbuterol administration significantly increased the freezing time. No significant difference was detected in the cued fear conditioning (G) among the four groups. N = 9–11 mice/group. Compared with the CLP group, ^##p < 0.01, ^∗p < 0.05. All data are mean ± SEM.