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. 2019 Jul 10;13:293. doi: 10.3389/fncel.2019.00293

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Copyright © 2019 Zong, Zhou, Ji, Jia, Tang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early clenbuterol treatment prevented the down-regulated CREB/BDNF and reversed the decreased synaptic proteins. (A,B) Clenbuterol prevented the down-regulated CREB/BDNF at 24 h and 16 days following CLP in the hippocampus. Representative Western blotting bands of pCREB, CREB, and mBDNF/proBDNF and quantitative analysis of the relative protein levels. (C,D) Clenbuterol ameliorated the decreased synaptic protein PSD95 and GluN2B induced by sepsis at 24 h and 16 days following CLP in the hippocampus. Representative Western blotting bands of PSD95, GluN2B, and synaptophysin and quantitative analysis of the relative protein levels. N = 3 mice/group. Compared with the CLP group, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. All data are mean ± SEM.