Table 1.

Antibacterial and anticancer compounds derived from deep-sea, desert, low cold, and volcanic Streptomyces.

Deep-sea Streptomyces-derived novel drugs
Compound	Structural class	Source	Activity	Depth	Region	Reference
Caboxamycin	Benzoxazole	Streptomyces sp. NTK 937	Antibacterial, antifungal, antitumor	3814 m	Atlantic	[71]
Ammosamides	Pyrroloiminoquinone	Streptomyces sp. CNR-698	Cytotoxic	1618 m	Bahamas	[72]
Spiroindimicins	Bisindole alkaloid	Streptomyces sp. SCSIO 03032	Cytotoxic	3412 m	Indian Ocean	[73]
Indimicins	Bisindole alkaloid	Streptomyces sp. SCSIO 03032	Cytotoxic	3412 m	Indian Ocean	[74]
Grincamycins	Glycoside	Streptomyces lusitanus SCSIO LR32	Cytotoxic	3370 m	South China Sea	[75]
Lobophorins E and F	Spirotetronate	Streptomyces sp. SCSIO 01127	Cytotoxic, antibacterial	1350 m	South China Sea	[76]
Lobophorins H and I	Spirotetronate	Streptomyces sp. 12A35	Antibacterial	2134 m	South China Sea	[46]
Marfuraquinocins	Sesquiterpenoid naphthoquinones	Streptomyces niveus SCSIO 3406	Cytotoxic, antibacterial	3536 m	South China Sea	[77]
Sungsanpin	Peptide	Streptomyces sp. SNJ013	Inhibitory activity to A549 with the cell invasion assay	138 m	Jeju Island	[78]
Ahpatinin	Peptide	Streptomyces sp. ACT232	Aspartic protease inhibitors	1174 m	Sagami Bay	[79]
Desotamides B−D	Peptides	Streptomyces scopuliridis SCSIO ZJ46	Antibacterial	3536 m	South China Sea	[80]
Marangucyclines A and B	Angucycline	Streptomyces sp. SCSIO 11594	Cytotoxic, antibacterial	2403 m	South China Sea	[47]
Grincamycin H	Glycoside	Streptomyces lusitanus SCSIO LR32	Cytotoxic	3370 m	South China Sea	[81]
Fradiamines A and B	Siderophore	Streptomyces fradiae MM456M-mF7	Antibacterial	806 m	Sagami Bay	[82]
Lobophorin K	Lobophorin	Streptomyces sp. M-207	Cytotoxic	1800 m	Central Cantabrian Sea.	[83]
Spiroindimicins G and H	Bisindole alkaloid	Streptomyces sp. SCSIO 03032	Anticancer	3412 m	South China Sea	[84]
Atratumycin	Cyclodepsipeptide	Streptomyces atratus SCSIO ZH16	Antituberculosis	3536 m	South China Sea	[41]
3-Hydroxyquinaldic acid derivative		Streptomyces cyaneofuscatus M-157	Cytotoxic	2000 m	Central Cantabrian Sea	[85]
Anthracimycin B	Macrolide	Streptomyces cyaneofuscatus M-169	Antibacterial	1500 m	Cantabrian Sea	[48]
Desert Streptomyces-derived novel antibacterial and cytotoxic drugs
Compound	Structural class	Source	Activity	Region	Reference
Chaxalactins	Macrolactone polyketides	Streptomyces sp. strain C34	Antibacterial	Atacama	[16]
Chaxamycins	Ansamycin-type polyketides	Streptomyces sp. strain C34	Antibacterial	Atacama	[23]
Atacamycins	Macrolactone	Streptomyces sp. C38	Enzyme inhibitor, antiproliferative	Atacama	[86]
Abenquines	Aminoquinone	Streptomyces sp. strain DB634	Enzyme inhibitor for phosphodiesterase type 4b	Atacama	[59]
2-Amino-N-(2-amino-3-phenylpropanoyl)-N-hydroxy-3-phenylpropanamide	Hydroxamic acid	Streptomyces strain WAB9	Antimicrobial	Saharan	[87]
Chaxapeptin	Peptide	Streptomyces leeuwenhoekii strain C58	Inhibitory activity in a cell invasion assay with A549	Atacama	[88]
Asenjonamides	Polyketide	Streptomyces asenjonii KNN 42.f	Antibacterial	Atacama	[21]
Pyridine-2,5-diacetamide	Pyridine alkaloid	Streptomyces sp. DA3-7	Antibacterial	Saudi Arabian Desert	[63]
Grincamycins	Angucycline	Streptomyces sp. XZHG99 T	Cytotoxic	Color Desert	[89]
Low cold Streptomyces-derived antibacterial and cytotoxic drugs
Compound	Structural class	Source	Activity	Region	Reference
2-Amino-3-dodecanol, norophthalmic acid, phthalic acid ester		Streptomyces avidinii SB9	Antibacterial	Arctic	[30]
Arcticoside, C-1027 chromophore-V	Benzoxazine	Streptomyces sp. ART5	Cytotoxicity activity	Arctic	[69]
Volcanic Streptomyces-derived antibacterial and cytotoxic drugs
Compound	Structure	Source	Activity	Region	Reference
Ohmyungsamycins A and B	Peptide	Streptomyces sp. SNJ042	Antibacterial, cytotoxic	Korean volcanic	[35]
Ulleungdin	Lasso peptide	Streptomyces sp. KCB13F003	Inhibited the invasion and migration of human lung carcinoma A549	Korean volcanic	[37]