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. 2019 Jul 1;2019:9096409. doi: 10.1155/2019/9096409

Figure 4.

Figure 4

KXS inhibited hyperphosphorylation of Tau by activating the PI3K/Akt/GSK-3β signaling pathway. KXS upregulated the PI3K/Akt signaling pathway, restored the phosphorylation activity of GSK-3β (Ser9), and decreased the degree of Tau phosphorylation caused by Aβ 25-35 and D-gal. Representative western images (a) and quantification (b) of protein related to the Tau signaling pathway in the rat hippocampus were represented. The area fraction of the hippocampus occupied by p-Tau (S396) was calculated using Image-Pro Plus software (c and d). Values were the mean ± SD (n = 6). ∗∗∗ P < 0.001 vs. the control group; # P < 0.05, ## P < 0.01, and ### P < 0.001 vs. the model group; $ P < 0.05 and $$ P < 0.01 vs. the Hup A group. Scale bar = 25 μm.