Table 2.
The concentrations of arachidonic acid and its metabolites in rat plasma determined by UFLC-MS/MS.
| Analytes | Control (ng/mL) | Model (ng/mL) | KXS (ng/mL) | Hup A (ng/mL) |
|---|---|---|---|---|
| 5-HETE | 0.807 ± 0.276 | 1.748±0.248∗∗∗ | 0.934 ± 0.192###$$ | 1.344 ± 0.0695## |
| 8-HETE | 39.19 ± 6.00 | 55.78±10.24∗∗∗ | 34.68 ± 7.88### | 38.21 ± 4.67### |
| 12-HETE | 35.19 ± 8.97 | 69.06±8.73∗∗∗ | 45.14 ± 7.57### | 52.82 ± 3.67### |
| 15-HETE | 28.33 ± 2.92 | 47.90±6.83∗∗∗ | 31.33 ± 2.04###$$$ | 48.22 ± 5.87 |
| AA | 1541 ± 228 | 3571±242∗∗∗ | 1684 ± 136###$$$ | 3076 ± 391## |
| LTB4 | 20.10 ± 6.68 | 34.92±6.78∗∗∗ | 27.63 ± 4.37# | 31.67 ± 4.58 |
| TXB2 | 474.1 ± 83.7 | 975.2±106.7∗∗∗ | 676.9 ± 64.4###$ | 850 ± 172 |
Values were the mean ± SD (n = 6). ∗∗∗ P < 0.001vs. the control group; # P < 0.05, ## P < 0.01, and ### P < 0.001vs. the model group; and $ P < 0.05, $$ P < 0.01, and $$$ P < 0.001vs. the Hup A group.