Table 4.
Summary of prognostic factor multivariate analysis in 1040 pathologically staged T1-2N1M0 breast cancer without postoperative radiotherapy
| HR | 95% CI | P-value | ||
|---|---|---|---|---|
| LRR | Age >40 y | 0.529 | 0.33–0.85 | 0.009 |
| IQ/CQ | 2.275 | 1.40–3.25 | <0.001 | |
| Molecular subtype | 0.001 | |||
| DM | Age >40 y | 0.645 | 0.46–0.91 | 0.013 |
| IQ/CQ | 1.505 | 1.09–2.08 | 0.013 | |
| Tumor size >3 cm | 2.144 | 1.54–2.98 | <0.001 | |
| Lymphovascular invasion | 2.033 | 1.39–2.98 | <0.001 | |
| Molecular subtype | 0.039 | |||
| LRFS | Tumor size >3 cm | 1.95 | 1.41–2.70 | <0.001 |
| Molecular subtype | 0.001 | |||
| DMFS | Molecular subtype | 1.372 | 1.00–1.88 | 0.05 |
| Tumor size >3 cm | 2.081 | 1.51–2.86 | <0.001 | |
| Lymphovascular invasion | 2.155 | 1.50–3.10 | <0.001 | |
| Molecular subtype | 0.025 | |||
| DFS | Age >40 y | 0.673 | 0.49–0.93 | 0.16 |
| Tumor size >3 cm | 1.915 | 1.41–2.60 | <0.001 | |
| Lymphovascular invasion | 1.996 | 1.41–2.83 | <0.001 | |
| Molecular subtype | 0.011 | |||
| BCSS | Age >40 y | 0.658 | 0.44–1.00 | 0.047 |
| Tumor size >3 cm | 2.030 | 1.38–2.99 | <0.001 | |
| Lymphovascular invasion | 1.755 | 1.07–2.88 | 0.026 | |
| Molecular subtype | 0.006 |
Note: P-values were calculated using an adjusted Cox proportional hazards model with forward conditional method.
Abbreviations: IQ, inner quadrant; CQ, central quadrant; LRR, locoregional relapse; DM, distant metastasis; LRFS, locoregional relapse-free survival; DMFS, distant metastasis-free survival; DFS, disease-free survival; BCSS, breast cancer specific survival.