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. 2019 Jul 9;12:5485–5497. doi: 10.2147/OTT.S197009

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© 2019 Ma et al.

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DANCR weakened the stimulatory effect of miR-34a-5p on docetaxel sensitivity of DTX-tolerated PC cells. DU145/DTX and PC3/DTX cells were transfected with miR-NC, miR-34a-5p, miR-34a-5p+pcDNA, or miR-34a-5p+pcDNA-DANCR, followed by detection of miR-34a-5p expression (A), IC50 value for DTX (B), colony number (C), cell proliferation (D and E), migration (F), invasion (G), and drug-resistance-related proteins LRP, P-gp, and MRP1 expression (H and I). *p<0.05.

Abbreviations: DANCR, anti-differentiation noncoding RNA; DTX, docetaxel; IC50, 50% inhibitory concentration; PC, prostate cancer.