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. 2019 Jul 9;12:5485–5497. doi: 10.2147/OTT.S197009

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© 2019 Ma et al.

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DANCR regulated docetaxel sensitivity of DTX-resistant PC cells via the miR-34a-5p/JAG1 axis. DU145/DTX and PC3/DTX cells were transfected with si-NC, si-JAG1, si-JAG1+anti-miR-NC, or si-JAG1+anti-miR-34a-5p, followed by the detection of JAG1 expression (A and B), IC50 value for DTX (C), colony number (D), cell proliferation (E and F), migration (G), invasion (H), and LRP, P-gp, and MRP1 proteins (I and J). (K) JAG1 expression in DU145/DTX and PC3/DTX cells following the transfection of si-NC, si-DANCR, si-DANCR+anti-miR-NC, or si-DANCR+anti-miR-34a-5p. *p<0.05.

Abbreviations: DANCR, anti-differentiation noncoding RNA; DTX, docetaxel; IC50, 50% inhibitory concentration; PC, prostate cancer; si-DANCR, small interfering RNA targeting DANCR.