. 2019 Jul 10;10:1556. doi: 10.3389/fmicb.2019.01556

TABLE 2.

Effect of efflux on the antibacterial activity of tested anticancer drugs against isogenic Pseudomonas aeruginosa strains.

	MIC, μg/mL

Anticancer drug	PAO1^a	PAO200^b	PAO750^c
Mitomycin C	2	0.062	0.031
Etoposide	512	128	16
Camptothecin	256	512	256
5-Fluorouracil	64	64	64
Cisplatin	128	128	128
Doxorubicin	256	32	2
TOB-CIP	32	4	2

^aP. aeruginosa antibiotic susceptible strain. ^bP. aeruginosa efflux-deficient strain lacking the MexAB-OprM pump. ^cP. aeruginosa efflux-deficient strain lacking five clinically relevant pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN, MexJK, and MexXY) and outer membrane protein OpmH.