Table 1.
Results. Shaded boxes indicate significant elevations in beta power with movement
| Patient | Age/Gender | Disease Duration (years) | Cardinal Symptom | UPDRS III ON/OFF Medication | Hemisphere | Beta Peak (Hz) | Movement | P value | Bicoherence Rest | Bicoherence Movement |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 51F | 6 | Tremor | 12/30 | L | 22.8 | Increase | 0.008 | N | Y |
| R | 25.5 | Increase | 0.03 | Y | Y | |||||
| 2 | 59M | 10 | Bradykinesia | 20/44 | L | 16.1 | Increase | 0.69 | N | Y |
| R | 22.8 | Increase | 0.15 | N | Y | |||||
| 3 | 64F | 11 | Tremor | 12/36 | L | 22.8 | Increase | 0.02 | Y | Y |
| R | 25.5 | Increase | 0.15 | Y | Y | |||||
| 4 | 55M | 16 | Bradykinesia | 13/66 | L | * | * | * | * | * |
| R | 20.14 | Increase | 0.008 | N | N | |||||
| 5 | 48F | 7 | Bradykinesia | 19/49 | R | 21.5 | Increase | 0.008 | N | N |
| 6 | 74F | 5 | Tremor | na/55 | L | 18.8 | Increase | 0.008 | Y | Y |
| 7 | 65M | 7 | Bradykinesia | 24/53 | R | 25.5 | Increase | 0.31 | Y | Y |
na= patient unable to tolerate levodopa
*
= inadequate LFP signal for analysis, Movement = change in beta power during continuous repetitive hand grasp movement, M=male, F=female, L=left, R=right, Y=yes, N=no, Wilcoxon rank sum test used for statistical analysis with significance set at P< 0.05. UDPRS (Unified Parkinson’s disease dating scale)