Table 2.
The uniformity and drug content of the loteprednol etabonate ointment formulations
Formulations | Manufacturing Method | Average Drug Loading ± SD(%, w/w) | RSD (%) |
---|---|---|---|
SRTOWP19 | Simple mixing for 6 minutes at 1,450 rpm at room temperature | 0.48 ± 0.01 | 2.87 |
SRTNWP19 | 0.49 ± 0.01 | 1.60 | |
HMICOWP19 | Melting at 65°C for 30 min and stirring at 1,450 rpm for 5 mins followed by immediate cooling at −20°C for 2 h, −4°C for 15 h | 0.49 ± 0.01 | 1.22 |
HMICNWP19 | 0.47 ± 0.00 | 0.91 | |
HMRTOWP19 | Melting at 65°C for 30 min and stirring at 1,450 rpm for 5 min followed by cooling at room temperature | 0.51 ± 0.02 | 3.27 |
HMRTNWP19 | 0.48 ± 0.01 | 1.05 |