TABLE 4.
Incidence Rate Ratio of Seizure Following Vaccination in Children Ages 1 to 5 Months Using the Self-Controlled Risk Interval Method*
| Analysis | total, n | Risk Interval, n | Control Interval, n | IRR (95% CI) |
|---|---|---|---|---|
| Febrile seizure | ||||
| Probable cases | 15 | 13 | 2 | 23 (5.13 to 100.8) |
| Probable and possible cases | 19 | 15 | 4 | 13 (4.36 to 39.6) |
| Febrile seizure cases who received RV5, DTaP-HepB-IPV, Hib, and PCV simultaneously on day 0† | ||||
| Probable cases | 9 | 8 | 1 | 28 (3.50 to 223.9) |
| Probable and possible cases | 12 | 9 | 3 | 11 (2.84 to 38.8) |
| Febrile seizure cases excluding those who had a non-CNS infection at the time of seizure | ||||
| Probable cases | 10 | 8 | 2 | 14 (2.97 to 65.9) |
| Probable and possible cases | 13 | 10 | 3 | 12(3.21 to 42.4) |
| All seizures with fever (including febrile seizure) | ||||
| Probable cases | 20 | 15 | 5 | 10 (3.82 to 28.9) |
| Probable and possible cases | 24 | 17 | 7 | 8.5 (3.52 to 20.5) |
| Seizures without fever | ||||
| Probable cases | 11 | 4 | 7 | 2.0 (0.59 to 6.83) |
| Probable and possible cases | 16 | 6 | 10 | 2.1 (0.76 to 5.78) |
Abbreviations:
CNS = Central nervous system
DTaP = Diphtheria-tetanus-acellular pertussis
HepB = Hepatitis B
Hib = Haemophilus influenzae type b
IPV = Inactivated poliovirus
IRR = Incidence rate ratio
PCV = Pneumococcal conjugate
RV5 = Rotavirus vaccine pentavalent
*
The risk interval was postvaccination days 0 to 1, and the control interval was postvaccination days 14 to 20.
†
This combination of vaccines was most common in this study population and includes all six vaccine types recommended for children in this age range.