Figure 8. Gata3^fl/flotof‐cre ^+/− knockout mice exhibit deterioration of DPOAEs only at older ages.

A, average DPOAE I/O function from control (gata3^fl/fl: white circles, 8–18 mice, 2–38 ears in each data point), heterozygous (gata3^+/flotof‐cre^+/−:blue triangles, 7–13 mice, 2–29 ears) and targeted knockout mice (gata3^fl/flotof‐cre^{+/ −}: red squares 5–14 mice, 1–34 ears). Mice younger than 1.7 months (left panel, two‐way ANOVA P = 0.21); mice between1.7 and 2.3 months (middle panel, P < 0.15); mice older than 7 months (right panel, P < 0.0001, control and heterorozygous n.s. from post hoc test). B, mean DPOAE threshold function from gata3^fl/fl (white circles, 8–20 mice; 13–30 ears), gata3^+/flotof‐cre^+/− (blue triangles, 8–11 mice; 13–19 ears) and gata3^fl/flotof‐cre^{+/ −}mice (red squares, 5–13 mice; 8–18 ears). Mice younger than 1.7 months (left panel, P < 0.001); mice between1.7 and 2.3 months (middle panel, P < 0.0001); mice older than 7 months (right panel, P = 0.0856). At all ages, control and heterorozygous were n.s. All values are shown as means ± SD.