Figure 9. Differential enhancement of LTD and LTP by spine ER is a general consequence of ICCR kinetics.

A, left, change in maximum CaM activation due to the presence of ER as a function of the spine NMDAR conductance and induction frequency; right, dependence of the modified plasticity (change in Δw) due to presence of ER on the NMDAR conductance and induction frequency. B and C, parameter sensitivity in the case of STDP inputs for the triplet (B) and doublet (C) spike pairing stimuli. (All results for comparison between ER⁻ control spine and an equivalent ER⁺ spine with 30 IP₃Rs; plasticity thresholds appropriately adjusted to give (in the ER⁻ spine) f _D = 1 Hz and f _P = 15 Hz for rate‐dependent plasticity, and, separately, STDP for −35 ms < Δt < 70 ms.) [Color figure can be viewed at wileyonlinelibrary.com]