Figure 11. ER Ca²⁺ store introduces a novel form of synaptic metaplasticity at individual CA1 dendritic spines.

Results from our analysis of frequency‐ and spike timing‐dependent plasticity are summarized by a comparison of the plasticity profiles for the reference ER⁻ spine (blue) and a spine with ER (red). The induction variable (which can stand for the synaptic input frequency f, or spike timing difference Δt) controls the activation of both NMDAR and ICCR, these dependencies being represented by tapering bars at the top. Also shown for comparison is the modified plasticity curve arising from a BCM‐like sliding LTP threshold (dashed curve). [Color figure can be viewed at wileyonlinelibrary.com]