Table 1.

Parameters governing membrane voltage dynamics

Parameter	Symbol	Value
Avogadro number	N a	6.023 × 1023 mol−1
Electric charge per Ca2+ ion	q Ca	3.2 × 10−19 C
Volume of (spherical) ER–/ER+ spine head	V spine	0.06 μm3
Resting membrane potential in spine/dendrite	u rest	−70 mV
Resistive coupling between spine head and parent dendrite	R C	100 MΩ
AMPAR conductance parameter	g A	0.5 nS
AMPAR rise time constant	τr A	0.2 ms
AMPAR decay time constant	τd A	2 ms
AMPAR current reversal potential	E A	0 mV
NMDAR conductance parameter	g N	65 pS in model synapse (gives ∆CaEPSP = 0.2 μm)
NMDAR rise time constant	τr N	5 ms
NMDAR decay time constant	τd N	50 ms
NMDAR current reversal potential	E N	0 mV
VGCC activation offset	u m	−20 mV
VGCC activation slope	k m	5 mV
VGCC activation time constant	τm	0.08 ms
VGCC inactivation offset	u h	−65 mV
VGCC inactivation slope	k h	−7 mV
VGCC inactivation time constant	τh	300 ms
Maximum depolarization during BAP in dendritic compartment	V 0	+67 mV
Fast time constant of BAP decay	τf	3 ms
Slow time constant of BAP decay	τs	40 ms
Effective number of co‐active synaptic inputs at dendritic compartment (rate‐dependent plasticity)	ρS	5 × 105 cm−2