Table 2.

Reaction rate parameters for Ca²⁺ buffering and extrusion

Parameter	Symbol	Value
Kinetic rate constants for interaction between Ca2+ and calbindin (CB)	k M0M1 k M1M2 k M1M0 k M2M1 k H0H1 k H1H2 k H1H0 k H2H1	174 μm −1 s−1 87 μm −1 s−1 35.8 s−1 71.6 s−1 22 μm −1 s−1 11 μm −1 s−1 2.6 s−1 5.2 s−1
Kinetic rate constants for interaction between Ca2+ and endogenous immobile buffer (CBP)	$k_{\mathrm{f}}^{\mathrm{CBP}}$ $k_{\mathrm{b}}^{\mathrm{CBP}}$	247 μm −1 s−1 524 s−1
Kinetic rate constants for interaction between Ca2+ and endogenous slow buffer	$k_{\mathrm{f}}^{s\mathrm{low}}$ $k_{\mathrm{b}}^{\mathrm{slow}}$	24.7 μm −1 s−1 52.4 s−1
Kinetic rate constants for interaction between Ca2+ and calmodulin (CaM)	k C0C1 k C1C2 k C1C0 k C2C1 k N0N1 k N1N2 k N1N0 k N2N1	6.8 μm −1 s−1 6.8 μm −1 s−1 68 s−1 10 s−1 108 μm −1 s−1 108 μm −1 s−1 4150 s−1 800 s−1
Kinetic rate constants for PMCA pump	k f PMCA k b PMCA k 3 PMCA k L PMCA	150 μm −1 s−1 15 s−1 12 s−1 3.33 s−1
Kinetic rate constants for NCX	k f NCX k b NCX k 3 NCX k L NCX	300 μm −1 s−1 300 s−1 600 s−1 10 s−1