Table 3.

Reaction parameters for mGluR–IP₃ signalling and ER Ca²⁺ handling (parameter values which have been changed from the original reference ( Doi et al., 2005 ) are highlighted)

Parameter	Symbol	Value
Time constant of glutamate pulse (alpha function)	τglu	1 ms
Max. amplitude of glutamate pulse at mGluR location	G max	300 μm
Kinetic rate constants for mGluR5‐G protein activation	a 1f a 2f a 3f a 4f a1b a2b a 3b a 4b a 5 a 6 a 7 a 8	11.1 μm −1 s−1 11.1 μm −1 s−1 2 μm −1 s−1 2 μm −1 s−1 2 s−1 2 s−1 100 s−1 100 s−1 116 s−1 0.001 s−1 0.02 s−1 6 s−1
Kinetic rate constants for phospholipase C (PLC) activation and production of IP3 and diacylglycerol (DAG)	b 1f b 2f b 3f b 4f b 5f b 1b b 2b b 3b b 4b b 5b b 6 b 7 b 8f b 9f b 8b b 9b b 10 b11 b 12	300 μm −1 s−1 900 μm −1 s−1 800 μm −1 s−1 1200 μm −1 s−1 1200 μm −1 s−1 100 s−1 30 s−1 40 s−1 6 s−1 6 s−1 2 s−1 160 s−1 1 μm −1 s−1 1 μm −1 s−1 170 s−1 170 s−1 8 s−1 2 s−1 8 s−1
Kinetic rate constants for IP3 degradation by IP3 3‐kinase (IP3K)	c 1f c 1b c 2f c 2b c 3	1111 μm −2 s−1 100 s−1 100 μm −1 s−1 80 s−1 20 s−1
Kinetic rate constants for IP3 degradation by IP3 5‐phosphatase (IP3K)	c 4f c 4b c 5	9 μm −1 s−1 72 s−1 18 s−1
Parameters for IP3 receptor kinetics	d 1 d 5 K inh a 2 α	0.8 μm 0.3 μm 0.2 μm 2.7 μm −1 s−1 937.5 μm −1 s−1 (corresponds to an open channel current of 0.15 pA when [Ca2+]ER = 0.5 mm)
Parameters for Hill‐type SERCA kinetics	K S V S	0.2 μm 1 μm s−1