Table 3. Association between negativity in toll-like receptors 1, 3, 7, and 9 and clinicopathological characteristics (%).

TLR status	All positive, n = 140	Negative in at least one receptor, n = 13	P value
N (%)	140 (92%)	13 (8%)
Age, years
< 65	38 (27)	5 (38)	0.519
≥ 65	102 (73)	8 (62)
Gender
Male	75 (54)	9 (69)	0.385
Female	65 (46)	4 (31)
Stage*
I	24 (17)	1 (8)	0.495
II	82 (59)	8 (62)
III	34 (24)	4 (31)
Lymph-node ratio
< 20%	108 (77)	10 (77)	1.000
≥ 20%	31 (22)	3 (23)
Missing data	1 (1)	0 (0)
Tumor size
≤ 30 mm	65 (46)	6 (46)	1.000
> 30 mm	70 (50)	7 (54)
Missing data	5 (4)	0 (0)
Perivascular invasion
Yes	37 (26)	6 (46)	0.185
No	77 (55)	5 (38)
Missing data	26 (19)	2 (15)
Perineural invasion
Yes	93 (66)	8 (62)	0.708
No	26 (19)	3 (23)
Missing data	21 (15)	2 (15)

Associations evaluated by Fisher’s exact test or linear-by-linear association test.

*Staging according to AJCC 8^th edition.