Table 4. Multivariate sub-group analysis of pancreatic ductal adenocarcinoma patients without post-operative adjuvant therapy.

Multivariate analysis, patients without adjuvant therapy, n = 74
		Hazard ratio	95% CI	P value
Age, years
< 65		1.00
≥ 65		1.47	0.73–2.96	0.276
Gender
Male		1.00
Female		1.14	0.67–1.95	0.630
Stage*	Lymph-node ratio
IA–IIA		1.00		0.004
IIB, III	< 20%	1.77	0.97–3.26	0.065
IIB, III	≥ 20%	3.37	1.63–7.00	0.001
TLR1
Negative, mild, or moderate		1
Strong		0.51	0.29–0.91	0.023

Multivariate Cox analysis. Multivariate analysis adjusted for age, gender, stage, lymph-node ratio, and post-operative adjuvant therapy.

*Staging according to AJCC 8^th edition.