Table 1. Demographics, disease characteristics.
Volumetric, neuropsychological scores and ocular motor measures for patients and control subjects.
|
CIS (n = 18) |
Controls (n = 17) | ||||
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Effect size | p-value | ||
| Demographics | |||||
| Age (yrs) | 36.50 (10.19) | 38.71(9.45) | -0.227 | 0.51 | |
| Education (yrs) | 16.36 (2.86) | 15.88 (3.20) | 0.160 | 0.64 | |
| Radiological | |||||
| Lesion volume (cm3) | 3.14 (3.32) | - | - | - | |
| Ventricle fraction (x10-3) | 10.21 (5.56) | 10.52 (4.02) | -0.065 | 0.66 | |
| Corpus callosum fraction (x10-3) | 2.30 (0.53) | 2.38 (0.31) | -0.171 | 0.62 | |
| Cerebellum fraction | 0.102 (0.010) | 0.103 (0.011) | -0.100 | 0.77 | |
| Cortical WM fraction | 0.340 (0.032) | 0.342 (0.027) | -0.082 | 0.81 | |
| Cortical GM fraction a | 0.425 (0.038) | 0.430 (0.039) | -0.110 | 0.59 | |
| Subcortical GM fraction (x10-3) | 30.04 (3.21) | 30.59 (2.25) | -0.200 | 0.56 | |
| Neuropsychological | |||||
| PASAT b | |||||
| Correct (%) | 78.92 (18.16) | 86.27 (11.31) | -0.479 | 0.17 | |
| SDMT | |||||
| Correct (no.) | 59.56 (10.79) | 64.18 (9.79) | -0.433 | 0.19 | |
| Ocular motor | |||||
| Pro-saccade | |||||
| Latency (ms) | 264.23 (52.99) | 251.85 (57.31) | 0.226 | 0.44 | |
| Directional error rate (%) a | 3.94 (3.40) | 2.63 (3.06) | 0.399 | 0.23 | |
| Anti-saccade | |||||
| Latency (ms) | 331.05 (55.66) | 330.26 (61.29) | 0.014 | 0.97 | |
| Directional error rate (%) | 9.26 (6.59) | 5.94 (4.31) | 0.575 | 0.087 | |
a Independent samples Mann-Whitney U Test.
b 17 CIS patients included.
WM = white matter, GM = grey matter, PASAT = paced auditory serial addition test, SDMT = symbol digit modalities test.