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. 2019 Jul 5;15(7):e1007078. doi: 10.1371/journal.pcbi.1007078

Fig 2. The prediction on an uncharted disease using Cardigan.

Fig 2

(A) The PPI network with disease genes associated to three different diseases (green, purple, and blue), is used to predict genes for the uncharted (red) disease. (B) The Caniza similarity is transformed into a weight for the red disease. (C) The query weight set (QWS)–the initial seed set for the diffusion process. (D) The final state of the network after the diffusion process. All genes have acquired a weight. These weights are used to rank all genes and constitute Cardigan’s prediction.