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. 2019 May 16;39(7):1379–1389. doi: 10.1161/ATVBAHA.118.312272

Figure 1.

Figure 1.

B cell overexpression of FcγRIIb (Fcγ receptor IIb) inhibits B cell activation and reduces atherosclerosis in males. A, Mean fluorescence intensity (MFI) for anti-FcγRIIb staining on B cells (B220+ IgM+) or CD11b+ cells from Apoe−/− or Btg Apoe−/− mice. B, Proliferation of purified B cells from Apoe−/− or Btg Apoe−/− mice after 72 h stimulation with anti-IgM whole IgG or Fab’ fragments. C, Levels of spleen B cell subsets (see Methods and Figure I in the online-only Data Supplement) in Apoe−/− or Btg Apoe−/− mice. D and E, Atherosclerosis quantified using Oil Red O–stained aortic root cryosections from male Ldlr−/− mice transplanted with WT or Btg bone marrow and fed western diet for 6 wk (D; n=12/group) or Apoe−/− or Btg Apoe−/− mice after 6 or 12 wk western diet (E, n=8–12 per group). Scale bar=100 µm. *P<0.05. αBCR indicates anti-B cell receptor; Btg, B cell transgenic; CPM, counts per minute; FO, follicular; MZ, marginal zone 1; T1, transitional stage 1; T2, transitional stage 2; and WT, wild-type.