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. 2019 May 16;39(7):1379–1389. doi: 10.1161/ATVBAHA.118.312272

Figure 3.

Figure 3.

Decreased FcγRIIb (Fcγ receptor IIb) expression on germinal center (GC) B cells in FcγRIIbΔAP-1 male mice enhances GC responses and increases atherosclerosis. A, Mean fluorescence intensity (MFI) of anti-FcγRIIb staining on B cells subsets (Figure I in the online-only Data Supplement) in Apoe−/− or FcγRIIbΔAP-1 Apoe−/− mice. B, Spleen GC B cell levels. C and D, Total serum IgG2c and IgG1. E, Atherosclerosis quantified using Oil Red O–stained aortic root cryosections from male Apoe−/− or FcγRIIbΔAP-1 Apoe−/− mice after 6-wk western diet. N=6 to 8 per group. Scale bar=100 µm. F–H, Atherosclerotic plaque composition was analyzed for proportions of cells (F) or MOMA2+-stained area (G). A single outlier was excluded from the WT group in F. *P<0.05. AP1 indicates activating protein-1; BM, bone marrow; FO, follicular; MZ, marginal zone; Sp, spleen; T1, transitional stage 1; and T2, transitional stage 2.