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. Author manuscript; available in PMC: 2019 Jul 17.
Published in final edited form as: Cell Rep. 2018 Feb 13;22(7):1835–1848. doi: 10.1016/j.celrep.2018.01.052

Figure 1. Loss of PTPN2 in Myeloid Cells Promotes Acute Intestinal Inflammation.

Figure 1.

Acute colitis was induced in WT and PTPN2-LysMCre mice.

(A–G) Shown are weight change (A), colon length (B), representative pictures from colonoscopy (C) and respective statistical analysis (D), myeloperoxidase (MPO) activity (E), spleen weight (F), and representative pictures and scoring of epithelial damage and inflammatory infiltration in the terminal colon (G).

Depicted are pooled results from two independent experiments with four to six mice per group. Asterisks denote significant differences (*p < 0.05, **p < 0.01, and ***p < 0.001; Mann-Whitney U test with Bonferroni correction). Scale bars represent 100 μm. Error bars represent means ± SD. See Figures S1–S3 for characterization of PTPN2-LysMCre mice.

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