TABLE 2.
Identified mutations in ETH-resistant M. tuberculosis strainsa
| ethA | ethA | ethA |
| M1R (62) | A234D (154) | C403G (62) |
| I9T (154) | t703 del (61) | R404L (154) |
| G11A (62) | Q246STOP (61) | G413D (61) |
| g32 del (154) | A248D (154) | c1254 del (154) |
| A20 ins (62) | Y250ST0P (154) | g1268 del (154) |
| a65 del (46) | cg754 ins (62) | c1290 del (61, 154) |
| H22P (62) | Q254P (154) | gc1322,1323 del (61) |
| Y32D (154) | Q254ST0P (154) | T453I (154) |
| a110 del (61, 154) | g768 del (61)* | Y461H (62) |
| G43S (61), C (46) | S266R (62) | R463D (61) |
| T44N (154) | Q269ST0P (62) | a1391 ins (62) |
| D49A (155) | Q271ST0P (154) | |
| Y50C (154) | L272P (62) | fabG-inhA regulatory region |
| P51L (46) | P288R (154) | g-17t (61) |
| D55A (61) | Q291ST0P (154) | c-15t (38, 61, 156) |
| D58A (46) | R292ST0P (154) | |
| T61M (62) | C294F (154) | inhA ORF |
| Y84D (46) | F302L (154) | I21T(61) |
| 1bp271 del (46) | T324 ins (154) | S94A (61) |
| cg282–283 del (154) | L328M (155) | I95P (151) |
| g337 del (154) | S329L (62) | |
| a338 ins (61) | L333R (155) | mshA |
| a342 del (154) | I338S (61)* | N111S* (62, 70) |
| G124D (62) | T342K (46) | Q128STOPa(70) |
| G139S (154) | d1029 del (154) | V171G(62) |
| Y140 STOP (154) | N345K (155) (154) | A187V(62) |
| Q165P (62) | A352P (154) | R273Cb (70) |
| W167STOP (154) | g1054 del (154) | G299Cb (70) |
| T186K (46) | P378L (154) | Q331STOPb (70) |
| g593 del (154) | A381P (46) | G356Db (Z0) |
| c613 del (155) | t1152 del (154) | E361Ab (70) |
| gt638–639 del (155) | G385D (61) | |
| D219G (154) | Y386C (62) | ethR |
| E223K (61) | S390F (154) | A95T (62) |
| g673 ins (154) | W391ST0P (154) | F110L (62) |
| tc675 ins (62) | T392A (61) | |
| T232A (155) | L397R (155) |
a
Asterisk (*), also found in ETH-sensitive strains.
b
Mutations found in in vitro cultures.