Table 1A:
Baseline Characteristics of the S3-TAVR and SAVR Cohorts
| S3-TAVRN = 1068 | SAVRN = 936 | P-ValueBefore Adjustment | P-ValueAfter Adjustment | |
|---|---|---|---|---|
| Clinical Characteristics | ||||
| Age (years) | 81.9 ± 6.6 | 81.6 ± 6.7 | 0.283 | 0.834 |
| Male (%) | 61.5 | 54.7 | 0.002 | 0.867 |
| STS Risk Score | 5.3 ± 1.3 | 5.8 ± 1.9 | < 0.001 | < 0.001 |
| Prior MI (%) | 16.1 | 17.7 | 0.330 | 0.939 |
| Prior PCI (%) | 32.1 | 26.9 | 0.011 | 0.882 |
| Prior CABG (%) | 28.0 | 25.5 | 0.214 | 0.966 |
| Cerebrovascular Disease (%) | 9.1 | 10.3 | 0.374 | 0.986 |
| Peripheral Artery Disease (%) | 28.3 | 31.9 | 0.073 | 0.911 |
| Atrial Fibrillation (%) | 35.7 | 34.8 | 0.692 | 0.957 |
| Creatinine > 2 mg/dl (%) | 7.6 | 5.4 | 0.054 | 0.704 |
| COPD (%) | 30.0 | 30.0 | 0.992 | 0.933 |
| Aortic Valve Area (cm2) | 0.7 ± 0.2 | 0.7 ± 0.2 | 0.443 | 0.876 |
| Mean Aortic Valve Gradient (mmHg) | 46.1 ± 12.6 | 44.7 ± 12.5 | 0.014 | 0.010 |
| Transfemoral Access (%) | 88.2 | 76.8 | < 0.001 | < 0.001 |
| Baseline Health Status | ||||
| KCCQ Overall Summary | 53.6 ± 21.7 | 52.9 ± 21.3 | 0.510 | 0.738 |
| KCCQ Physical Limitations | 56.1 ± 24.2 | 55.8 ± 24.4 | 0.774 | 0.923 |
| KCCQ Total Symptoms | 58.0 ± 22.4 | 57.8 ± 22.1 | 0.818 | 0.988 |
| KCCQ Quality of Life | 48.1 ± 23.9 | 46.6 ± 23.3 | 0.165 | 0.921 |
| KCCQ Social Limitation | 51.2 ± 29.9 | 50.8 ± 29.8 | 0.763 | 0.921 |
| SF-36 Physical Summary | 36.3 ± 8.7 | 36.0 ± 8.7 | 0.427 | 0.847 |
| SF-36 Mental Summary | 47.8 ± 11.4 | 47.7 ± 11.7 | 0.901 | 0.201 |
| EQ-5D Utilities | 0.75 ± 0.16 | 0.74 ± 0.17 | 0.076 | 0.738 |
Abbreviations: STS – Society of Thoracic Surgeons; MI – Myocardial infarction; PCI – percutaneous coronary interventions; CABG – coronary artery bypass grafting; NYHA – New York Heart Association Class; LV – left ventricle; KCCQ – Kansas City Cardiomyopathy Questionnaire