Table 1.

Methods Used to Measure SOS Characteristics by DeLeve et al (1999).⁸

Outcome	Histology	Morphology	Inflammation	Biochemical parameters	Physical parameters
Method	Light microscopy	Electron microscopy	Immunohistochemistry	Blood sampling	Various
Specific measures	•CV endothelial damage •Coagulative necrosis of hepatocytes •CV subendothelial hemorrhage •Sinusoidal hemorrhage •CV subendothelial fibrosis •CV adventitial fibrosis •CV inflammation •Lobular inflammation	•Injury to SECs •Rupture of sinusoidal wall •Accumulation of blood in space of Disse •Hepatocyte necrosis	•Kupffer cells •Circulating monocytes •Circulating ED-1 and ED-2	•Hematocrit •White cell count •Bilirubin (total and direct)	•Weight gain •Ascites •Hepatomegaly

CV, central vein; SECs, sinusoidal endothelial cells; SOS, sinusoidal obstruction syndrome.