Table 3.
Association of Expression of MicroRNAs With Clinicopathological Factors of HCC.
| Factors | N (50) | miR-21 level (2−ΔΔCt) |
miR-122 level (2−ΔΔCt) |
||
|---|---|---|---|---|---|
| miR-21 | P value | miR-122 | P value | ||
| HCC + LC | 43 | 19.26 ± 3.15 | 0.0001 | 10.58 ± 2.07 | 0.0001 |
| HCC minus liver cirrhosis (−ve) | 7 | 10.63 ± 2.78 | 6.16 ± 1.58 | ||
| AFP | |||||
| ≥400 ng/dl | 34 | 15.7 ± 4.8 | 0.639 | 8.17 ± 2.92 | 0.729 |
| <400 ng/dl | 16 | 16.44 ± 5.34 | 9.02 ± 2.61 | ||
| Tumor number | |||||
| 1 | 30 | 16.08 ± 5.23 | 0.725 | 8.51 ± 2.91 | 0.291 |
| 2 | 18 | 15.54 ± 4.5 | 9.41 ± 2.55 | ||
| Tumor size | |||||
| ≤3 cm | 12 | 15.36 ± 4.8 | 0.668 | 9.29 ± 2.34 | 0.753 |
| >3 cm | 37 | 16.08 ± 5.06 | 8.64 ± 2.95 | ||
| TNM grade | |||||
| I–II | 38 | 5.9 ± 2.50 | 0.0001 | 6.55 ± 3.9 | 0.0001 |
| III–IV | 12 | 19.25 ± 3.01 | 11.66 ± 1.34 | ||
| CTP score | |||||
| HCC + LC | 43 | 19.26 ± 3.15 | 0.121 | 10.58 ± 2.07 | 0.103 |
| Liver cirrhosis (+ve) | 25 | 16.52 ± 4.75 | 9.3 ± 2.65 | ||
| HCC | 7 | 10.63 ± 2.78 | 6.16 ± 1.58 | ||
| LC | 25 | 16.52 ± 4.75 | 9.3 ± 2.65 | ||
HCC, hepatocellular carcinoma; LC, liver cirrhosis; TNM, tumor node metastasis; AFP, alpha-fetoprotein; CTP, Child-Turcotte-Pugh.