Table 3.
Accuracy of mSEPT9, CEA and the combination in detecting colorectal cancer.
| Tests | Sensitivity | Specificity | Accuracy |
|---|---|---|---|
| mSEPT9 | 71.8% (77/105) | 66.7% (38/57) | 71.0% (115/162) |
| CEA | 50.5% (53/105) | 78.9% (45/57) | 60.5% (98/162) |
| Combination# | 85.7% | 54.4% | 74.7% |
| P value | |||
| mSEPT9 vs CEA (2-sided) | 0.001 | 0.206 | 0.061 |
| mSEPT9 vs CEA (1-sided) | 0.001 | 0.103 | 0.030 |
| mSEPT9 vs Combination (2-sided) | 0.039 | 0.250 | 0.532 |
| mSEPT9 vs Combination (1-sided) | 0.020 | 0.125 | 0.266 |
| CEA vs Combination (2-sided) | 0.000 | 0.009 | 0.009 |
| CEA vs Combination (2-sided) | 0.000 | 0.005 | 0.004 |
#Combination refers to either mSEPT9 (methylated septin 9) or CEA (carcinoembryonic antigen) was positive among participants who had both tests done (n = 162).