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. 2019 Jul 17;9:10347. doi: 10.1038/s41598-019-46749-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of MNC energy status during aging. Graph shows the ATP/AMP ratio, as a marker of the energy status of MNC isolated from peripheral blood (PB), obtained from healthy population with an age between 5 and 106 years. The population is divided by decades. The values decrease progressively with aging. * or ** indicate, respectively, a significant difference for p < 0.05 or p < 0.01 between the marked decade and the previous decade.