Fig. 2.

Comparison of domain organization in eukaryotic and prokaryotic plasminogen activators. The corresponding domains for the eukaryotic proteins t-PA, urokinase, and desmoteplase – finger F, epidermal growth factor EGF, kringle K1, kringle K2, serine protease P – are depicted with individual colors. Glycosylation sites are marked with a green Y symbol, phosphorylation sites with a purple P symbol, catalytic residues with a red asterisk *, disulfide bridges with a blue line, and the site of the proteolytic cleavage is marked with a yellow triangle Δ. The individual domains α, β, and γ are marked with corresponding colors for prokaryotic proteins streptokinase and staphylokinase. The missing domains in homologous proteins are illustrated with a dashed line.