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The fibrin binding sites of tissue plasminogen activator. The residues interacting with fibrin are shown as orange beads. Two charged patches are involved in binding of fibrin: (i) Arg7–Lys10 in the t-PA’s finger domain and (ii) residues His432, Arg434, Asp460, and Arg462 in the serine protease domain. The lysine binding site at Asp236 binds both C-terminal and intra-chain lysines of partially degraded fibrin.
