Fig. 2. BH3 mimetics disrupt mitochondria in a BAX- and BAK-dependent but BH3-independent manner.

HCT-116 WT, DKO (BAX/BAK deficient) and OctaKO cells were exposed to Z-VAD.fmk (30 µM) for 0.5 h, followed by a combination of A-1331852 (100 nM) and A-1210477 (10 µM) for 4 h and assessed for mitochondrial structural changes by electron microscopy. Scale bars: 500 nm