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. 2019 Jul 17;9:10350. doi: 10.1038/s41598-019-46601-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urine high-resolution mass spectrometry in CKD rats. (A) Representative acrylamide gel under denaturing conditions and subsequent staining with Coomassie blue of urines from rats with CKD compared to control rats (sham). The identified proteins were mainly between 55 and 72 KDa. (B) SerpinA3 was identified with high-resolution mass spectrometry with a high coverage (44.7%) in urine samples from CKD rats.