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. 2019 Jul 17;10:3042. doi: 10.1038/s41467-019-10759-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — TCER-1 acts cell non-autonomously to suppress immunity and promote longevity. a–j TCER-1 expression in any somatic tissue suppresses PA14 resistance. Mean survival (hours) of L4 larvae transferred to PA14. a–e Expression in tcer-1 mutants. Wild type (WT, black, 60.68), tcer-1 (blue, 96.31) and tcer-1 mutants expressing TCER-1 (red) under control of a endogenous promoter (70.91) or promoters expressed in b intestine (gly-19, 55.3), c neurons (rgef-1, 62.32), d muscles (myo-3, 64.0) or e hypodermis (col-12, 71.67). f–j Expression in tcer-1;glp-1 mutants. f Native expression. Wild type (WT, 60.68), glp-1 (79.2), tcer-1;glp-1 (orange, 80.3) and tcer-1;glp-1 mutants expressing TCER-1 under the control of endogenous promoter (44.0). g–j Tissue-specific expression. WT (47.61), glp-1 (59.52), tcer-1;glp-1 (67.98) and tcer-1;glp-1 mutants expressing TCER-1 (red) under the control of promoters expressed in g intestine (22.45), i muscles (25.03) or j hypodermis (47.15). h Neurons: WT (75.3), glp-1 (102.34), tcer-1;glp-1 (126.59) and neuron-expressed TCER-1 (84.31). k–o TCER-1 expression in any somatic tissue extends tcer-1;glp-1 mutant’s lifespan on OP50. Mean survival (days) on OP50. k, l WT (18.7), glp-1 (29.32), tcer-1;glp-1 (17.11) and tcer-1;glp-1 mutants expressing TCER-1 under k endogenous promoter (24.14) and l tissue-specific expression in intestine (25.66). m–o WT (18.44), glp-1 (27.35), tcer-1;glp-1 (21.46) and tcer-1;glp-1 mutants expressing TCER-1 in m neurons (29.98), n muscles (29.26) and o hypodermis (28.14). Survival data analyzed using Kaplan−Meier test. P values adjusted for multiplicity where applicable. Asterisks indicate statistical significance <0.05 (*), <0.001 (***) and <0.0001 (****) and their color denotes the strain of comparison. Assays in some panels were conducted in the same biological replicate so their controls are shared. Details of number of animals and data from additional trials in Supplementary Tables 4A (panels a–e), 4B (f–j) and Supplementary Data 1 (k–o)