Figure 6.

A Model Was Provided to Illustrate the Role of miR-92a-2-5p and let-7b-5p in Diabetic Cardiomyopathy

Roles of miR-92a-2-5p and let-7b-5p in diabetic cardiomyopathy. miR-92a-2-5p and let-7b-5p were downregulated in mitochondria of db/db mice. Re-expression of miR-92a-2-5p increased mitochondrial Cytb expression, decreased mitochondrial ROS production, and eventually protected against lipid deposition and cardiac dysfunction in db/db mice. Let-7b-5p showed a similar regulation on Cytb as miR-92a-2-5p in the mitochondria; however, let-7b-5p also negatively regulated IRS1 and increased palmitate deposition, leading to unimproved cardiac function in db/db mice.