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. 2019 Jun 28;17:436–447. doi: 10.1016/j.omtn.2019.06.012

Figure 1.

Figure 1

ZCL-082 Reduced the Number, Viability, and Proliferation of FGSCs

(A) Chemical structure of ZCL-082. (B) Morphology of FGSCs treated with various concentrations of ZCL-082 (i, control; ii, 0.125 μM; iii, 0.25 μM; iv, 0.5 μM; v, 1 μM; vi, 2 μM; vii, 4 μM; and viii, 8 μM). Scale bar, 50 μm. Control was DMSO. (C) Number of FGSCs per 35-mm plate at various concentrations of ZCL-082. Control was DMSO. (D and E) Fold change in cell viability under different concentrations was detected by CCK8 assay at 24 h (D) and 48 h (E). Control was DMSO. (F and G) Cell proliferation was detected by EdU assay at various concentrations of ZCL-082 (F) and their results were statistically significant (G) (i, control; ii, 0.125 μM; iii, 0.25 μM; iv, 0.5 μM; v, 1 μM; vi, 2 μM; vii, 4 μM; and viii, 8 μM). Control was DMSO. Scale bar, 50 μm. Values are presented as mean ± SEM of three biological replicates. *p < 0.05, **p < 0.01.