Figure 4.

Serum creatinine clearance change from baseline during study treatment and post-treatment follow-up periods among participants on TDF-containing antiretroviral regimens. The horizontal axis represents the study weeks and the vertical axis represents changes in serum creatinine clearance from baseline. The dark gray boxes represent the interquartile ranges for changes in serum creatinine clearance for participants on pharmacologically-boosted TDF-containing antiretroviral regimens, and the light gray boxes represent the interquartile ranges for changes in serum creatinine clearance for participants on all other TDF-containing antiretroviral regimens. The hashed vertical line represents the end of dosing and start of follow-up. Abbreviations: COBI, cobicistat; PI, protease inhibitor; TDF, tenofovir disoproxil fumarate.