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. 2019 Jul 11;10:1480. doi: 10.3389/fimmu.2019.01480

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Copyright © 2019 Bui, Kolodziej, Lamanna, Elgass, Sehgal, Rudloff, Schwenke, Tsuchimochi, Kroon, Cho, Maksimenko, Cholewa, Berger, Young, Bourke, Pearson, Nold and Nold-Petry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of IL-1Ra on the heart in murine BPD-PH. At day 28 of the BPD-PH model, hearts were stained with Sirius Red and whole heart slices were analyzed. (A) One representative image per group is depicted. Scale bars, 100 μm; n = 7–10 per group. (B) Quantification of Sirius Red staining in n = 7–10 pups per group. Data shown as mean ± SEM. (C–E) Real-time PCR was performed on whole heart homogenates for (C) Lgals3, (D) Ccl2 and (E) Nppb. Results were normalized to Actb and depicted as fold-change relative to the lowest expressed gene ± SEM. **P < 0.01 and ***P < 0.001 for air vehicle vs. hyperoxia vehicle; ^#P < 0.05 and ^##P < 0.005 for hyperoxia vehicle vs. hyperoxia IL-1Ra.