Figure 7.

Sustained treatment effects of IL-1Ra on day 60 of life. The pulmonary vasculature of 60 days-old BPD-PH mice was visualized by cine-angiography. (A) One representative synchrotron radiation angiogram of the pulmonary vasculature per group is depicted. The red squares highlight poor regional perfusion of distal blood vessels in hyperoxia vehicle mice and the green square shows the amelioration of vascular development afforded by IL-1Ra. (B) Quantification of absolute blood vessel number; n = 3–5 mice per group. Data are mean ± SEM. *P < 0.05 and **P < 0.005 for air vehicle vs. hyperoxia vehicle; ^#P < 0.05 and ^##P < 0.005 for hyperoxia vehicle vs. hyperoxia IL-1Ra.