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Schematic illustration of the fabrication of PGA/Alum and its action mechanism. PGA/Alum induces the innate immunity such as antigen uptake and delivery by DCs to lymph nodes, thereby leading to the enhanced antigen-specific cellular and humoral immunities. Consequently, PGA/Alum improves the cross-reactive immunity of influenza vaccine antigens against heterologous influenza virus, with increases of CTL and ADCC activities.
