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. 2019 Jul 10;10:772. doi: 10.3389/fphar.2019.00772

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Copyright © 2019 Bailly, Vidal, Bonnemaire, Kraeber-Bodéré, Chérel, Pallardy, Rousseau, Garcion, Lacoeuille, Hindré, Valable, Bernaudin, Bodet-Milin and Bourgeois

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In a 32-year-old woman suffering from an astrocytoma WHO grade II, conversion into a secondary Glioblastoma multiforme (GBM) manifested 10.6 months after initial diagnosis. Following standard treatment consisting of surgery, radiotherapy, and chemotherapy with temozolomide, four cycles of ²¹³Bi-DOTA-substance P were applied. The total activity injected amounted to 8.0 GBq of the therapeutic isotope. The T1-weighted enhanced MRI examination revealed shrinkage of the tumor by 32% (Krolicki et al., 2018).