Figure 2.

The protection process of ZIKV in female reproductive tract. Immune system mechanism protects against ZIKV infection in female reproductive tract. (1) ZIKV infect vaginal epithelial cells, (2) infected cells produce IFN-α,β,γ, and possibly IFN-ε which initiates the intracellular antiviral state (3) immune cells increases antigen presentation leading to T and B cell activation, (4) effector B cells secrete ZIKV-specific antibodies and effector cytotoxic T cells kill ZIKV infected cells; (5) Finally, the IS mechanism control and protect against ZIKV.