Table 2.
Characteristics of lung cancers and study outcome by study arm, throughout the 10-year follow-up
| Total | Control arm | Intervention arm | P-values | ||
|---|---|---|---|---|---|
| (N = 4099) | (N = 1723) | (N = 2376) | |||
| Lung cancer incidence | 158 (3.9%) | 60 (3.5%) | 98 (4.1%) | 0.29 | |
| Lung cancer rate (per 100 000) | 407.0 | 372.6 | 431.5 | 0.37 | |
| Person-years (incidence) | 38 816 | 16 102 | 22 714 | ||
| Lung cancer stage | |||||
| I | 62 (39.2%) | 13 (21.7%) | 49 (50.0%) | 0.0004a | |
| II | 9 (5.7%) | 5 (8.3%) | 4 (4.1%) | ||
| III | 26 (16.5%) | 10 (16.7%) | 16 (16.3%) | ||
| IV | 61 (38.6%) | 32 (53.3%) | 29 (29.6%) | ||
| Lung resection | |||||
| None | 78 (49.4%) | 44 (73.3%) | 34 (34.7%) | <0.0001b | |
| Pneumonectomy | 1 (0.6%) | 0 | 1 (1.0%) | ||
| Lobectomy/segmentectomy | 79 (50.0%) | 16 (26.7%) | 63 (64.3%) | ||
| Lung cancer histology | |||||
| Squamous cell carcinoma | 30 (24.4%) | 12 (30.0%) | 18 (21.7%) | 0.25c | |
| Adenocarcinoma | 78 (63.4%) | 23 (57.5%) | 55 (66.3%) | ||
| Small cell carcinoma | 10 (8.1%) | 4 (10.0%) | 6 (7.2%) | ||
| Large cell carcinoma | 5 (4.1%) | 1 (2.5%) | 4 (4.8%) | ||
| Carcinoma NOSd | 35 | 20 | 15 | ||
| Lung cancers not screen detected | 86 (54.4%) | 59 (98.3%) | 27 (27.6%) | <0.0001 | |
| Total deaths | 243 (5.9%) | 106 (6.2%) | 137 (5.8%) | 0.61 | |
| Overall mortality rate (per 100 000) | 618.4 | 653.9 | 593.5 | 0.45 | |
| Lung cancer deaths | 80 (2.0%) | 40 (2.3%) | 40 (1.7%) | 0.14 | |
| Lung cancer mortality rate (per 100 000) | 203.6 | 246.8 | 173.3 | 0.12 | |
| Person-years (mortality) | 39 293 | 16 210 | 23 083 | ||
Resection for benign histology was not accounted in the table, it is thereafter summarized: 3 cases in LDCT arm, rate of resection for benign histology 4.5% (3/67); 1 case in control arm, rate of resection for benign histology 5.9% (1/17).
a
Proportion of stage I.
b
Proportion of lung resection compared with no lung resection.
c
Carcinoma NOS excluded.
d
Carcinoma NOS: carcinoma not otherwise specified.