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. 2019 May 15;30(7):1071–1079. doi: 10.1093/annonc/mdz132

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© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Somatic mutational landscape of 78 familial breast cancers grouped by BRCA status determined by original clinical diagnosis. (A) Clinical information for each sample includes: germline pathogenic variant status from clinical testing of BRCA1 and BRCA2 genes, gender, age at diagnosis, tumour morphological type, histological grade and biomarker status for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). (B) The number of somatic indels per sample. (C) Number of somatic single nucleotide variants (SNVs). (D) Number and type of somatic structural rearrangements. IC NST, Invasive Carcinoma No Special Type; MDL, Mixed Ductal-Lobular Carcinoma; DCIS, Ductal Carcinoma In Situ; ILC, Invasive Lobular Carcinoma; Med. Ca., Medullary Carcinoma; Met. Ca., Metaplastic Carcinoma; Muc. Ca., Mucinous Carcinoma; #, number; n/a, not available.