Table 2.
Association between minor alleles of VDR variants and log-25(OH)D compared with major alleles by maternal race and study.a
| Variant | Race-study group | Allelic Count |
Mean 25(OH)D, nmol/L by allele |
Unadjusted Beta (95%CI) | Adjusted Beta (95%CI)b | ||
|---|---|---|---|---|---|---|---|
| Major | Minor | Major | Minor | ||||
| rs11168293 | C., B. | G 983 | T 137 | 43.3 | 42.0 | −0.03(−0.14, 0.08) | −0.04(−0.13, 0.05) |
| C.,W. | G 756 | T 316 | 59.8 | 60.7 | 0.03(−0.04, −0.09) | 0.04(−0.02, 0.10) | |
| E., B. | G 425 | T 47 | 48.9 | 58.4* | 0.21(0.08, 0.34)*** | 0.22(0.10, 0.35)**** | |
| E., W. | G 1151 | T 443 | 76.9 | 75.3 | −0.02(0.06, 0.02) | −0.02(−0.05, 0.02) | |
| rs2853559 | C., W. | G 696 | A 388 | 59.4 | 61.8 | 0.07(0.00, 0.13)** | 0.08(0.02,0.14)*** |
| E., B. | G 384 | A 108 | 49.1 | 51.8 | 0.08(−0.03, 0.19) | 0.08(−0.02,0.18) | |
| rs7971418 | C., B. | A 575 | C 459 | 43.1 | 43.7 | 0.05(−0.03, 0.12) | 0.07(0.00,0.14) |
| E., B. | A 254 | C 202 | 47.2 | 54.2* | 0.13(0.03, 0.23)** | 0.10(0.01,0.19)** | |
| rs11574114 | C., B. | C 1017 | T 119 | 43.7 | 39.1* | −0.09(−0.20, 0.03) | −0.10(−0.21,0.01) |
| E., B. | C 442 | T 40 | 50.3 | 49.4 | 0.00(−0.15, 0.14) | −0.07(−0.20,0.06) | |
| rs2408876 | C., B. | T 562 | C 526 | 43.7 | 41.0 | −0.07(−0.14, 0.00) | −0.04(−0.10,0.03) |
| C., W. | T 641 | C 461 | 61.8 | 58.5* | −0.05(−0.11, 0.01) | −0.04(−0.09,0.02) | |
| E., B. | T 264 | C 234 | 51.2 | 47.2* | −0.08(−0.17, 0.02) | −0.07(−0.16,0.03) | |
| E., W. | T 1001 | C 709 | 76.7 | 75.5 | −0.02(−0.05, 0.01) | −0.02(−0.05,0.01) | |
| rs4760650 | C., B. | G 909 | T 199 | 43.4 | 42.4 | −0.03(−0.10, 0.05) | −0.01(−0.08,0.06) |
| C., W. | G 812 | T 250 | 60.0 | 59.8 | 0.00(−0.06, 0.06) | 0.03(−0.02,0.09) | |
| E., B. | G 423 | T 75 | 49.3 | 52.4 | 0.05(−0.07, 0.18) | 0.06(−0.06,0.17) | |
| E., W. | G 1234 | T 372 | 76.3 | 77.6 | 0.03(0.00, 0.06) | 0.03(0.00,0.06)** | |
Vitamin D receptor, VDR;25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; C., B., CPP study, Black race; C., W., CPP study, White race; E., B., EVITA study, Black race; E., W., EVITA study, White race.
Groups not shown for each SNP did not pass quality control steps.
Adjusted for batch number (in EVITA only), year drawn (in EVITA only), site (CPP), season of blood draw, sample age, ancestry (for black race/ethnicity models only) and maternal age.
p < 0.05 based on a test for trend.
Betas and 95% CI that reach statistical significance at p < 0.05.
Betas and 95% CI that reach statistical significance at p < 0.01.
Betas and 95% CI that reach statistical significance at p < 0.001.