Table 4.
Mean 25(OH)D concentration by genetic variant for selected CYP27B1 by maternal race and study.a
| Variant | Race-study group | Allelic Count |
Mean 5(OH)D, nmol/L by allele |
Unadjusted Beta (95%CI) | Adjusted Beta (95%CI)b | ||
|---|---|---|---|---|---|---|---|
| Major | Minor | Major | Minor | ||||
| rs10877011 | C., B. | T 1017 | G 135 | 43.3 | 42.7 | −0.04(−0.16, 0.09) | −0.06(−0.1, 0.06) |
| C., W. | T 741 | G 339 | 59.8 | 60.3 | 0.01(−0.06, 0.08) | 0.0(−0.06, 0.07) | |
| E., B. | T 425 | G 71 | 56.4 | 48.3* | 0.17(0.05, 0.30)*** | 0.15(0.04, 0.26)*** | |
| rs12318065 | C., B. | C 920 | A 144 | 42.6 | 44.8 | 0.08(−0.02, 0.17) | 0.07(−0.02, 0.15) |
| E., B. | C 345 | A 97 | 49.6 | 52.9 | 0.09(−0.02, 0.19) | 0.11(0.02, 0.21)** | |
| rs12582311 | C., W. | A 868 | G 244 | 59.3 | 62.4 | 0.05(−0.03,0.12) | 0.05(−0.03, 0.12) |
| E., B. | A 316 | G 154 | 49.7 | 52.2 | 0.10(0.00, 0.19)** | 0.09(0.00, 0.18)** | |
| rs701007 | C., B. | C 843 | A 259 | 42.9 | 41.9 | −0.05(−0.14, 0.03) | −0.04(−0.12, 0.04) |
| C., W. | C 650 | A 470 | 61.0 | 59.0 | −0.03(−0.10, 0.03) | −0.03(−0.09, 0.03) | |
| E., B. | C 363 | A 135 | 50.7 | 47.7 | −0.07(−0.18, 0.03) | −0.09(−0.18, 0.00)** | |
1 alpha-hydroxylase, CYP27B1; 25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; C., B., CPP study, Black race; C., W., CPP study, White race; E., B., EVITA study, Black race; E., W., EVITA study, White race.
a
Groups not shown for each SNP did not pass quality control steps.
b
Adjusted for batch number (in EVITA only), year drawn (in EVITA only), site (CPP), season of blood draw, sample age, ancestry (for black race/ethnicity models only) and maternal age.
*
p < 0.05 based on a test for trend.
**
Betas and 95% CI that reach statistical significance at p < 0.05.
***
Betas and 95% CI that reach statistical significance at p < 0.01.